Bone Marrow - Stem Cells
Why bone marrow?
The use of bone marrow (Bone Marrow Aspirate, BMA) in clinical applications of regenerative medicine is based on the fact that the contents of the bone marrow (ancestral and nucleated stem cells, platelets, lymphocytes, cytokines, etc.) support the regeneration processes of tissues and tissues.
The use of Bone Marrow Aspirate Concentrate (BMAC) cells focuses mainly on mesenchymal stem cells (MSCs), with the ability to self-renew and differentiate into multiple cell types. The application of biological bone marrow treatments can offer solutions to musculoskeletal pathologies, spinal disorders, chronic wound care and critical limb ischemia, through effective change of the local microenvironment facilitating and promoting tissue healing and regeneration.
BONEPLEXTM: A good beginning makes a good ending
Amvyx's BONEPLEXTM system enables fast and safe harvesting, concentration and recovery of active myeloid stem cells with minimal processing at the point of care (POC). The procedure involves the aspiration, centrifugation, isolation and infusion of stem cells.
Initially, bone marrow is aspirated through specialized needles (trocars), which rupture bone cortex until marrow reserves are accessed. There are many different needle designs available, but the design features and aspirations dynamics greatly affect the quality and viability of the collected marrow tissue, as well as cellular yields.
Always innovative, amvyx has designed the specialized MedulOSTM anatomical trocar that enhances aspiration and bone marrow collection quality. With a diamond cut needle tip, and custom thin channel walls, the MedulOSTM delivers excellent flow through the generous inner diameter of the 11G tube, while limiting the inlet opening to a minimum outer diameter of 8G.
With five (5) alternating fenestrations in the cannula, MedulOSTM aspirates high quality stem and progenitor cells from various levels into the bone, while limiting contamination with peripheral blood. The non-traumatic end of the cannula allows for safe deep insertion to access the rich medullary reserves.
The specialized harvest syringe connected to the MedulOSTM has an oversized inlet hole (3.5 x Luer Lock hole) for increased flow. Combined with a patented vacuum locking mechanism, marrow aspiration becomes effortless and fast,while preserving cell integrity.
Safety, repeatability and efficiency
User and patient safety is the highest priority. The consumables used in competitive BMAC systems have design features that potentially increase the risk of contamination. BONEPLEXTM disposable, sterile separation consumables include resealable dual-access injection valves that are aseptically disinfected before material is added or removed.
BONEPLEXTM consistently achieves high concentrations of nucleated cells regardless of patient age, which means that more cells with therapeutic potency are eventually delivered to the site of application. Sample processing with the 4th generation separator apparatus of the BONEPLEXTM kit, yields repeatedly 4.5 times higher concentration of nucleated cells (Total Nucleated Cell counts, TNC) than untreated marrow aspirations from the iliac crest. In combination with the company's PRPs, BONEPLEXTM is the ultimate myelocyte stem cell therapy for the musculoskeletal system and selected applications in the integumentary system.
Shoulder:
- Rotator cuff-partial tears
- Biceps tendinosis
- Acromio-clavicular joint dysfunction and pain
- Levator scapulae tendinosis
- Knee
- Patellar tendinitis/tendinosis
- Osgood-Schlatter's disease
- Degenerative arthritis
- Rheumatoid arthritis
- Chondromalacia patella
- Elbows
- Epicondylitis—medial &lateral—tennis/ golfer’s elbow!
- Ulnar collateral ligament injury
- Distal biceps tendon partial tear
- Hip/Pelvis/SI joints
- Piriformis syndrome
- Greater trochanteric bursitis
- Osteonecrosis of the femoral head
- Spine
- Sacroiliac joint
- Facet joints
- Ankle & Foot
- Chronic ligament strains
- Chronic Achilles tendinosis
- Chronic partial tendon tear
- Plantar fascitis
- Arthritic joints
